Thursday, November 7, 2019

Free Essays on Hindus

Hindus The story, â€Å"Hindus† tells about the fading away of cultures, in this case, one’s attitude towards one’s country if one has been away from one’s country for quite sometime. I think that the story fits under the section ‘Caste and Class’ because it focuses on the people’s way of thinking towards their countries’ social values and class. For example, Pat was in favor of American values and way of life. He was once in jail for selling an Indian painting, which was a family heirloom, just for money. The story also tells how one’s family background heritage gets faded away once one stays away from one’s country for too long. It seems that the Indians in America who are immigrants, have a much better off life and social class here in America than in their own country. For example, the Patels, who had been in the States for eighteen years, had been fortunate in having only sons, who were even pursuing higher education; with daughters, there would have been pressure on them to return to India for a proper, arranged marriage. (482) Therefore, with the different attitudes the characters in the story have on their heritage/country, the story should fit into the category of ‘Caste and Class’.... Free Essays on Hindus Free Essays on Hindus Hindus The story, â€Å"Hindus† tells about the fading away of cultures, in this case, one’s attitude towards one’s country if one has been away from one’s country for quite sometime. I think that the story fits under the section ‘Caste and Class’ because it focuses on the people’s way of thinking towards their countries’ social values and class. For example, Pat was in favor of American values and way of life. He was once in jail for selling an Indian painting, which was a family heirloom, just for money. The story also tells how one’s family background heritage gets faded away once one stays away from one’s country for too long. It seems that the Indians in America who are immigrants, have a much better off life and social class here in America than in their own country. For example, the Patels, who had been in the States for eighteen years, had been fortunate in having only sons, who were even pursuing higher education; with daughters, there would have been pressure on them to return to India for a proper, arranged marriage. (482) Therefore, with the different attitudes the characters in the story have on their heritage/country, the story should fit into the category of ‘Caste and Class’....

Monday, November 4, 2019

Argument paper - Heart disease only affects the old Essay

Argument paper - Heart disease only affects the old - Essay Example Most people, however, do not feel that they need to worry about heart disease until they are older. Despite the fact that most people believe the heart disease is an illness of age and inevitable, through changing lifestyles and addressing bad habits throughout the population heart disease could be almost all but eliminated. Although heart disease is the leading cause of death in the United States, heart disease is more of a symptomatic result rather than a singular affliction. One of the greatest myths about heart disease is that if it runs in the family there is nothing that can be done to prevent it. The American Heart Association established the idea that this is a myth and that if people take better care of themselves through becoming active, controlling cholesterol, eating better and maintaining healthy weight and sugar control that it is possible to avoid the eventuality of heart disease. The American Heart Association also discusses the problem of people believing that age is relevant to cardiovascular diseases. It is true that more often cardiovascular disease will affect a senior citizen; however the young and middle-aged can also develop heart problems, especially now that obesity has become an epidemic. There are many people who believe that the way in which they live when they are young, has no bearing on what their life will be like when they are older. In many cases, people believe that the young have the ability to have poor lifestyles and survive while they do not need to actually worry about it until they enter middle age (Bell). However, evidence shows that this is not the case. In fact, the way in which a mother takes care of her health during pregnancy appears to have a great deal of effect on the way in which a child has certain health opportunities throughout his or her life (Wintour and Owens 10). Therefore, if the effects that a mother has on a childs

Saturday, November 2, 2019

The Power of the Media Tycoon Essay Example | Topics and Well Written Essays - 2250 words

The Power of the Media Tycoon - Essay Example Today, the power of the media and the few people that control it, have been compared to world leaders in their ability to sway opinion and effect change. How does this power compare to the power of a US President While the media tycoons have the legal limitations of any business owner that answers to stockholders and a board of directors, they have the power to move public opinion, initiate social change, and influence foreign policy to an extent greater than any elected public official. In the United States almost all the information available comes from a media outlet. Academic research is generally reserved for the small circle of specialists that have a position that offers them an interest and gives them exposure to the topic. These articles will occasionally get anecdotally quoted by the media, but the reports can be used for the outlet's own self-serving agenda. Selected quotes taken out of context can mislead the viewers in an attempt to sway public opinion. These opinion-centric newscasts exert enormous control over what people think and how they think about it. The ability to slant the news is even more significant in light of the increasing concentration of media ownership. The period of 1984 - 1999 saw the number of major owners go from 50 to 15 (Hasen 1626). The reduced number of outlets translates to an increased numbers of viewers and more influence. Media owners such as Rupert Murdoch can stack ... Reporters and pundits can be richly rewarded by presenting material in line with the network's political views. They can also be summarily punished and fired for developing a politically unpopular story of a scandal or major corruption. The network owner leverages these strengths to highlight or diminish a story's importance in the viewer's mind. The president is unable to cap a story or keep facts out of the viewer's homes. The recent events surrounding the investigation into the firings of the US Attorneys is evidence of the president's lack of ability to control the news. It is solely in the hands of the network and the network leadership. When comparing a media tycoon's power in regards to public opinion to a president, it is helpful to consider the information disseminated during a national presidential election. Presidents and candidates are limited to advertising and 'free' news spots. They are limited in the amount of time and coverage they can get. News conferences can help a president get exposure for a program or to promote a political stance, but television news can paint the portrayal with an opinionated slant. The news is not simply responding to a market and giving viewers 'what they want'; they are actively promoting a social agenda. During a recent national election, coverage varied widely from Fox to NBC to CBS. They varied in the amount of coverage on issues such as race and gender and according to Larson, "...although network news shows generally compete for the same audience, have the same operating procedures, and have similarly trained workers, their stories differed" (23). News presentation has the ability to focus attention on a given event and make the event important

Thursday, October 31, 2019

Some exam questions I need explained Essay Example | Topics and Well Written Essays - 750 words - 1

Some exam questions I need explained - Essay Example PEST (Political, Economical, Socio-cultural, Technological factors) analysis is an important strategic planning tool. It proves to be a useful stepping stone for the analysis of external factors for an organization. It is also useful to analyze the feasibility of a certain project with reference to different external factors that might affect its execution. This model covers a broader aspect of the prevailing environmental factors than SWOT analysis. Porter’s 5 Forces: This model was developed by Michael E. Porter in 1980. He formulated the model on the basis of 5 competitive forces that tend to determine the nature of every industry. Organization can evaluate the level of competition, profitability and acceptance rate of an industry with the help of these forces; threat of new competitors, bargaining power of the suppliers, rate of rivalry in the industry, bargaining power of customers, threat of substitutes. Value Chain Analysis: It is considered to be a systematic approach; involves a sequence of functions and actions that build value for the organization. Value chain analysis plays a major role in the development of competitive advantage in the market. It equals to the cumulative value that is provided by the organization. Experience Curve Effect: This concept was formulated in 1966 by Bruce Henderson. Experience is considered to be an asset for any organization. The concept promotes the increment of this asset in different forms in the organization, for example, hiring of experienced resources, collaboration with other companies etc. According to the experience curve effect; if a company gains greater experience in a specific field or production process then 25 to 30 % of the costs can be decreased. It can help the organization to evaluate the success rate of the company and increase revenues. BCG (Boston Consulting Group) Matrix: is a portfolio management model. It categorizes the products of the organization

Tuesday, October 29, 2019

Outsourcing or Exporting America Essay Example for Free

Outsourcing or Exporting America Essay With the new economic slump, many people are trying to find ways to rebuild the economy and find the cause of the downward spiral that has recently plagued our country. In the quack of high unemployment, and many families losing their homes, many of the economists and researchers are looking to the outsourcing of jobs to other countries as the culprit for the dilemma. Is his belief true or false? The answer lies within each person’s individual belief, because politicians do not give all the information available about this new crises and the reason for it. In a year of presidential elections, one only needs to look at the previous election to see that this same topic was prevalent. In 2004, John Kerry accused George W. Bush of â€Å"exporting† jobs to other countries so big business could save money. In fact, N. Gregory Mankiw stated that the outsourcing of jobs was just another type of trade on an international level. Even at that time, many opponents realized that the government was trying to make excuses for high unemployment and the loss of jobs in this country. With the end of the election, the topic lost steam and lay in the background for years (Drezner, 1; Dobbs, 1). Now, in the smoke filled world of foreclosures, banks going under and financial giants losing their grasp of the world, the issue of outsourcing has again reared its head. Why? Because the majority of the public believe that the exporting of jobs is a major factor in the current slump. While manufacturing jobs have been lost to countries for lower wages, now the middle manager and white collar jobs are being shipped overseas to companies that charge much less then their American counterparts. This leaves the middle class American with few options and young Americans with unfulfilled dreams (Drezner, 1; Dobbs, 1). Both sides of the argument believe that they are in the right. Those that applaud the globalization and outsourcing to other countries, truly or blindly believe that it is the best option for this country. They even believe that it will help to create higher paying jobs for Americans, while the mundane and manufacturing jobs are done elsewhere for less money. They fool themselves with this notion. The truth of the matter is that American companies shut down factories and outsource middle management or call center activities; they are hurting the American worker and the American economy (Dobbs, 1). Look around and see the economy failing, banks losing, real estate stagnant. While the stock market roller coasters from downward spirals to euphoric rises, the economy is more imbalanced than ever. Multinational corporations will continue to layoff workers in the United States to give those jobs to people in other countries for less money. Is destroying our country worth a few dollars per employee? Most American would not agree. They would take up rank and fight, but until they have the correct information, and the government stops skewing the truth, the American people will suffer and the economy will fail.

Sunday, October 27, 2019

Pathogenesis and Course of AIDS

Pathogenesis and Course of AIDS Title: Give a detailed account of the pathogenesis and course of AIDS. Undergraduate Degree Level Essay 2,500 words   The study of HIV / AIDS is a vast topic and the literature on the subject fills many volumes. In this essay therefore we propose to take an overview of some of the most current views and developments in the field with particular emphasis on the pathophysiology of HIV / AIDS In 1997 the World Health Organisation gave the assessment that since HIV / AIDS had been recognised, over 11.7 million people had died of the condition world wide and at the time of publication 30 million more were thought to be infected with 16.000 new infections occurring daily. Current predictions estimate that at the current rate of infection 55 million will have died by 2010. (Greek R et al 2002) Perhaps the most worrying of all of these gargantuan statistics was the fact that of the 30 million infected, 27 million were thought to be unaware of their condition. Quite apart form the devastation the disease causes on a personal basis, the vast majority of those infected are young adults which has enormous implications for the social structure of their communities. (Graham B S 1998) Pathophysiology of the condition As we have implied earlier, the volume of work relating to the pathophysiology of HIV / AIDS is enormous, in this essay we therefore intend to â€Å"cherry-pick† a number of selected topics and discuss them in some detail. The implications of genetics in both the acquisition of HIV and the subsequent development of AIDS is a rapidly expanding field. The interaction between virus and host is a multifaceted and extremely complex one. From the point of infection onwards there is usually a significant HIV viraemia even though in the early stages, the patient may be completely asymptomatic. It is known that the degree of virus replication is directly related to the degree of T-cell depletion and equally correlates with progression of the disease process. It would therefore appear that HIV induces symptomatic disease process by replicating in, and subsequently destroying, CD4 and T-cells thereby weakening the immune system. (Stilianakis NI et al 1997), .Different hosts and indeed different genotypes of hosts (see on) have differing patterns of disease expression. CD4 and T-cell levels are rapidly diminished in the early stages of the disease but are not restored by effective anti-viral therapy if given later in the disease. (Littman D R 1998) One area of obvious interest is in those who appear to survive with HIV for a longer than average time before it progresses to AIDS. A study by Dean (M et al 1995) proved to be seminal in this area, with a prospective study of nearly 2,000 men. The authors considered the status of CCR5 genotype and its relation to the likelihood of disease progression. The paper is both long an detailed, but provides a strong evidence base for further research (Berwick D 2005). In essence, the main findings of the paper were that most people have two normal alleles for the CCR5 gene, but 1 in 7 has one mutant allele (technically 32bp deletion), which means that they still have one normal allele (heterozygous genotype). 1 in 100 have two mutant alleles. The rates of mutation are highly racially specific ranging from 11% in Caucasians to The significant finding in the study was that none of the 1,300 HIV +ve people in the study had the homozygous mutation, 15% of the HIV +ve had the heterozygous genotype, so the heterozygous genotype clearly does not protect against infection, but the significant difference is that the average transition time from HIV to AIDS for the homozygous man was 10 years whereas the average transition time for the heterozygous genotype was 13 years. Possibly even more significant is the fact that of the 17 people in the entry cohort who were homozygous for the mutation and in the high risk of infection group, none of them had contracted HIV. It would therefore appear that the CCR5 mutation plays some critical role early in the primary stages of HIV infection since it appears that HIV infection can be blocked if a functioning version of this receptor is not present. During the later stages of the infection it would appear that other co-receptors (the CXCR4 has been implicated) can take over the role as the properties of the virus evolve within the host. (McMichael A 1998). On this basis some authors have suggested a classification taxonomy that differentiates HIV virus sub-types on the basis of their CCR5 receptor affinity. (Berger E A et al 1998). It would appear that the viruses eventually evolve into the R5X4 (in this classification) type which allows them to eventually produce the full blown AIDS syndrome. The absence of one working CCR5 allele simply retards the evolutionary progress. (Chan DC et al 1998), This is in congruity with other pathophysiological observations. For example, it is already known that the influenza virus enhances the CXCR4 dependent HIV infection. It is thought that the pathway of influenza infection activates the CD4 and T- lymphocytes which, in turn utilise the CXCR4 co-receptors on the cell. This activation would therefore appear to increase the potential number of HIV target cells in an individual which would clearly accelerate viral spreading. (AIDS RU 1998). In the same way, syphilis is known to be an active agent in increasing CCR5 expression and is also known to be a strong predisposing factor for the overall HIV risk whereas it does not induce CXCR4 (Lafeuillade A et al 1997), From our considerations thus far it is clear that the pathophysiology of the HIV infection revolves around the build up (replication) of the HIV virus in the CD4 and T-cells. This is not an immediate process as new T-cells are being produced (albeit from a progressively dwindling stock) of non-infected bone marrow stem cells. (Greek R et al 2002) Why are there a number of specific AIDS-defining diseases? This is a vast area in its own right. The presence of HIV in a T-cell does not immediately destroy the cell, but alters its function. Each T cell has a number of receptor areas determined by the V region of the receptor gene, and these determine the subclass (and specificity) of the T-cell itself . Each sub-type has specific receptor sequences that allow it to recognise a broad spectrum of histocompatibility complexes. (Hecht F M et al 1998) The HIV presence alters the expression of the V site region and thereby allows certain pathogens to be sub-optimally challenged (Connors M et al 1997). It is the nature of HIV infection that specific colonies (or sub-types) of CD4 T-cells are depleted before others are altered. This translates clinically into the situation where certain pathogens ( viz. Pneumocystis carinii, Mycobacterium avium-intracellulare, and cytomegalovirus. ) can be present, virtually unchallenged even though the T-cell population may be apparently quite active. Typically the reservoir of CD4 and CD8 lymphocytes may remain skewed despite the overall apparent adequacy of circulating T-cells. (Nosik M N et al 2002), Alongside this altered state of immunity a number of other immune-related phenomenon can be seen including some types of autoimmunity and AIDS-related malignancies including squamous cell carcinoma of skin, testicular cancer, myeloma, Hodgkins disease. Some investigators have recently demonstrated a statistically very significant relationship between a profound immunodeficiency state (with marked CD4 depletion) and the development of a non-Hodgkins lymphoma, presumably by a similar mechanism. (Voulgaropoulou et al. 1999) Aggressive anti-viral therapy has been partially successful in reducing the frequency of malignancies such as Kaposis sarcoma and B cell lymphomas. Study of these progressive â€Å"blind spots† in the T-cell’s response mechanisms suggest that a diversity of the T-cell receptor V genes can be re-established in patients with an undetectable viraemia for longer than a six month period, which is strongly suggestive of the fact that regeneration of uninfected (or immuno-protected) naà ¯ve precursors is possible with aggressive therapy. (Connors M et al 1997), There is an overall increase in the incidence of AIDS-related malignancies. This is not thought to be due to any new or progressive evolution of the HIV virus, but mainly due to the development of new and more effective antiretroviral therapies together with more efficient prophylaxis for opportunistic infections which is allowing the HIV / AIDS patient to survive for longer in the immunodeficient state. Treatment We do not intend to present any detail relating to specific treatments for HIV / AIDS but will make a few general comments. A current pressing question for clinicians is â€Å"can antiretroviral therapy ever be safely stopped?† The current generations of protease inhibitors that are combined with non-nucleoside reverse transcriptase inhibitors are capable of reducing viraemia to undetectable levels. (Jordan R et al 2002), Clinical experience suggests that as soon as treatment is stopped, viraemia tends to rapidly recur at pre-treatment levels. This strongly suggests an ability of the HIV to enter a latent phase or to remain in immunoprivilleged sites (such as the testes and central nervous system). Like most retro-viruses, the HIV has the ability to integrate its DNA into the host genome even though it may remain transcriptionally dormant and thereby avoid cellular detection and apoptosis until it enters its replication cycle (Wei X et al 1995), It is difficult to draw specific conclusions from a presentation such as this as the overriding impression that one gets from any examination of the literature on the subject is both the speed and the diversity of the research that is currently being undertaken world-wide. There appear to be two main thrusts as far as research is concerned. One is the development of new antiretroviral and immunoactive therapeutic measures to try to combat the pathophysiology of the disease process itself, the other is the search for a vaccine which would ultimately be the â€Å"holy grail† in this particular pandemic. (Malegapuru W et al 2002) One of the main stumbling blocks as far as vaccine development is concerned is the difficulty in targeting the antigenicity of the frequently changing immunological profile of the HIV. (Musey L et al 1997). Considerable interest has been shown in the persistently sero-negative partners of sero-positive patients who have been frequently found to have a specific ability to produce interleukin 2 from peripheral mononuclear cells together with the detectable presence of HIV specific IgA in mucosal secretions. (Mazzoli S et al 1997), Many vaccine research projects are currently exploring the avenue of designing vaccines which have the potential to stimulate and produce HIV-specific CD8 cytotoxic T-cell responses to the HIV. Initial primate studies suggest that prevention of infection at a mucosal site (as opposed to parenteral infection) is actually possible as mucosal infection is relatively inefficient and only a small number of HIV virons are likely to be involved. (Matano T et al 1998). Phase one clinical trials have been undertaken in this regard already but with disappointing results as the immunogenic responses that have been engendered are 5-10 times lower than those produced by HIV infection with a comparatively short half-life. (Mugerwa R D et al 2002). There are a number of approaches with recombinant viral entities of various types which have also met with limited success Currently it would appear that vaccine candidates can manage to induce CD8 cytotoxic T lymphocyte responses with killing activity across different strains which can last a significant length of time, but they are yet unable to induce neutralising antibody with activity against typical transmitted HIV virus. (Lenzer J 2003) References AIDS RU 1998 AIDS research updates. Science 1998; 280: 1856-1894 Berger E A et al 1998 Nature 391:240, 1998 Berwick D 2005 Broadening the view of evidence-based medicine Qual. Saf. Health Care, Oct 2005; 14: 315 316. Chan DC, Kim PS. 1998 HIV entry and its inhibition. Cell 1998; 93: 681-684 Connors M, Kovacs J, Krevat S, Gea-Banacloche JC, Sneller MC, Flanigan M, et al. 1997 HIV infection induces changes in CD4+ T-cell phenotype and depletions within the CD4+ T-cell repertoire that are not immediately restored by antiviral or immune-based therapies. Nature Med 1997; 3: 533-540 Dean M. et al 1996 Science 273:1857, 1996 Finzi D, Siliciano RF. 1998 Viral dynamics in HIV-1 infection. Cell 1998; 93: 665-671 Graham B S 1998 Science, medicine, and the future: Infection with HIV-1 BMJ, Nov 1998; 317: 1297 1301 Greek R, Pandora Pound, and Nancy L Haigwood 2002 Animal studies and HIV research BMJ, Jan 2002; 324: 236 ; Hecht FM, Grant RM, Petropoulos CJ, Dillon B, Chesney MA, Tian H, et al. 1998 Sexual transmission of an HIV-1 variant resistant to multiple reverse-transcriptase and protease inhibitors. N Engl J Med 1998; 339: 307-311 Jordan R, Lisa Gold, Carole Cummins, and Chris Hyde 2002 Systematic review and meta-analysis of evidence for increasing numbers of drugs in antiretroviral combination therapy BMJ, Mar 2002; 324: 757 ; Lafeuillade A, Poggi C, Tamalet C, Profizi N. 1997 Human immunodeficiency virus type 1 dynamics in different lymphoid tissue compartments. J Infect Dis 1997; 175: 804-806. Lenzer J 2003 Claim that smallpox vaccine protects against HIV is premature, say critics BMJ, Sep 2003; 327: 699 ; Littman D R 1998 Chemokine receptors: keys to AIDS pathogenesis? Cell 1998 May 29;93(5):677-80. Malegapuru W, Makgoba, Nandipha Solomon, and Timothy Johan Paul Tucker 2002 Science, medicine, and the future: The search for an HIV vaccine BMJ, Jan 2002; 324: 211 213 ; Matano T, Shibata R, Siemon C, Connors M, Lane HC, Martin MA. 1998 Administration of an anti-CD8 monoclonal antibody interferes with the clearance of chimeric simian/human immunodeficiency virus during primary infections of rhesus macaques. J Virol 1998; 72: 164-169 Mazzoli S, Trabattoni D, Lo Caputo S, Piconi S, Ble C, Meacci F, et al.1997 HIV-specific mucosal and cellular immunity in HIV-seronegative partners of HIV-seropositive individuals. Nature Med 1997; 3: 1250-1257 McMichael A. 1998 T cell responses and viral escape. Cell 1998; 93: 673-676 Mugerwa R D, Pontiano Kaleebu, Peter Mugyenyi, Edward Katongole-Mbidde, David L Hom, Rose Byaruhanga, Robert A Salata, and Jerrold J Ellner 2002 First trial of the HIV-1 vaccine in Africa: Ugandan experience BMJ, Jan 2002; 324: 226 229 ; Musey L, Hughes J, Schacker T, Shea T, Corey L, McElrath MJ. 1997 Cytotoxic-T-cell responses, viral load, and disease progression in early human immunodeficiency virus type 1 infection. N Engl J Med 1997; 337: 1267-1274 Nosik M N, Matsevich G R 2002 HIV-1 chemokine receptors and their role in the pathogenesis of AIDS Vopr Virusol. 2002 Jan-Feb;47(1):4-8. Stilianakis NI, Dietz K, and Schenzle D, 1997, Analysis of a model for the pathogenesis of AIDS Mathematical Biosciences, 145, 27-46 Voulgaropoulou et al. 1999 Distinct Human Immunodeficiency Virus Strains in the Bone Marrow Are Associated with the Development of Thrombocytopenia, J Virol 1999 Apr;73(4):3497-504 Wei X, Ghosh SK, Taylor ME, Johnson VA, Emini EA, Deutsch P, et al.1995 Viral dynamics in human immunodeficiency virus type 1 infection. Nature 1995; 373: 117-122 ############################################################# 17.3.06 PDG Word count 2,514

Friday, October 25, 2019

Educational Philosophy :: Education Teaching Teachers Essays

Educational Philosophy Webster’s dictionary defines the word educate as to develop and cultivate mentally or morally; train; instruct; teach. I would like to be someone who educates because educators, or teachers, help people and have an influence over their students. A teacher is someone who earns respect and is looked up to by others. I want to be a teacher because I want to be able to help people and make an impact on someone’s life. When I become a teacher, I want to have an orderly and structured classroom. I want the children in my class to be comfortable and in the best environment for learning. When the children come into the gymnasium, I want them to go into the locker room and get dressed to participate and come out and line up on a certain spot, which is assigned to them. Hopefully, by lining them up it will discourage discrimination and let the children make new friends. The walls in the gymnasium and the locker room will display all the rules and procedures of the class, the gymnasium, the locker room, and the school. It will also have the policies and various procedures of the school for the students to refer to. The activities will be appropriate. I will inform the students as to where and when equipment is and used. I will inform them as to when it is appropriate to get the equipment out and to put it back in its place. I see myself as a progressive teacher according to my styles of teaching. I will establish a non-authoritarian classroom. This means that I will be asking my students for help in making the rules and consequences for the gymnasium. We will decide the severity of the rule that was broken and match it with an equally severe punishment. We will decide as a group what kind of organization we will have in the gymnasium. There will be incentives for good behavior in physical education class. Rewards will vary for many reasons, such as weather, time of year, time, etc. I will inform my students as to what type of teaching style I liked when I was in school and ask them for their opinions on what type they would like, however that does not necessarily mean I will use what they suggest. I might integrate some of their suggestions into my own teaching style.